In Vivo Inflammation Models

Inflammix has a broad panel of IACUC-approved mouse models of acute or chronic inflammation and autoimmunity. We have the experience to adapt existing models to your needs and the creativity to develop new models to meet your specific unique requirements. Fee free to contact us for an initial consultation.

Mouse Models of Acute Inflammation

  • LPS-induced cytokine production (IL-6, TNFα)

  • Casein-induced neutrophil peritonitis

  • E. coli-induced neutrophil peritonitis

  • Thioglycollate-induced macrophage peritonitis

  • LPS/D-galactosamine-induced liver failure

  • Staph. Enterotoxin B (SEB)-induced liver failure

  • Uric acid-induced gout (air pouch)

  • Delayed-type hypersensitivity (ear thickness)

  • IL-12/IL-18-induced INFγ

Mouse Models of Intermediate or Chronic Inflammation

  • Collagen-induced arthritis

  • Anti-collagen antibody-induced arthritis (with LPS synchronization)

  • Citrullinated fibrinogen-induced arthritis in HLA-DR4 transgenic mice

  • Ovalbumin-induced allergic asthma

  • NOD mouse spontaneous diabetes

  • NZB/W F1 spontaneous lupus

  • Anti-CD40-induced colitis in SCID mice

  • DSS-induced colitis

  • Skin allografts

  • Sponge matrix allografts

We are not limited to these. Tell us what you need and we can add something new.